Dear Dr. Gott: I am writing to find out what you think we should do, because all the specialists are baffled about my husband's illness. Six months ago, he began to have seizures for no known reason. He was in ICU for three weeks with a diabetic specialist, an endocrinologist and a neurologist on his case. They ran every test possible to rule out this or that for the cause of the seizures. All tests came back negative. His glucose is under control. He continues to have "spells", with symptoms of lead feet, sweating legs, headache and the smell and taste of burnt beef in his mouth.

He takes synthroid, 175 mcg, once a day. I am wondering and have asked if there is a possibility of him having a reaction to this medication. It falls on deaf ears.

Last night, I called the ambulance, as he was having one of those spells again and could not walk. His speech and thought processes were slow. When the EMTs arrived, he seemed normal. Four hours of observation confirmed that everything was normal.

This is not normal for him and never has been. I was questioned why I was wasting precious time calling an ambulance for something like this. I responded I am not a doctor and cannot diagnose what is happening. We have done everything the doctors have required and still want answers as to the cause. I feel they are treating the effects without checking into the possibility of it being a reaction to medication.

Reply: Seizures are commonly brought on by sudden, abnormal electrical activity of the brain. Causes include head injury, drug overdose, brain tumour, accidental poisoning, low blood sugar or sudden lack of oxygen to the brain. They are divided primarily into two categories – focal or partial. Focal seizures occur on both sides of the brain, partial seizures on one side. They may present with muscle spasms, unusual sensations (such as your husband's taste of burnt beef), loss of consciousness and more. In some cases, the cause is never identified, but the activity doesn't necessarily represent epilepsy.

I would like to address your husband's daily use of synthroid. When was he diagnosed as being hypothyroid? Is there a correlation between the time he went on the medication and the time the seizure activity began? The dosage is a rather strong one. Was he begun on a lower amount and increased over time? Has he been tested on a timely basis? The inert ingredients in synthroid include confectioners' sugar, acacia, lactose monohydrate, magnesium stearate, povidone and talc.

The dose also includes FD&C blue No. 1 Aluminum Lake and D&C red Nos. 27 and 30 Aluminum Lake dyes. Perhaps he is responding to the coloring. Were he on a lesser dose, the dyes would vary in intensity.

If he had a CT scan to rule out a brain tumour, didn't sustain a head injury within the past month or so, hasn't been accidentally poisoned, and can't attribute the activity to a recent occurrence, perhaps the medication is the cause of the seizure activity.

I recommend he ask his physician for a little indulgence. If the medication isn't vital, perhaps they can compromise on a trial without it. He might consider diet modification – include cabbage, Brussels sprouts, lima beans, broccoli, cauliflower, potatoes, bananas, and supplemental vitamins B and C. Fats, sugars, red meats and eggs should be consumed in moderation. And he should exercise 15 to 20 minutes every day unless his doctor says otherwise.

If no improvement is found, request a referral to a new neurologist for a second opinion.

To provide related information, I am sending you a copy of my Health Report 'Thyroid Disorders'. Other readers who would like a copy should send a self-addressed stamped number ten envelope and a $2 cheque or money order to Newsletter, PO Box 167, Wickliffe, Ohio 44092-0167. Be sure to mention the title or print an order form off my website at www.AskDrGottMD.com.

Dr. Peter H. Gott is a retired physician and the author of several books, including 'Live Longer, Live Better', 'Dr. Gott's No Flour, No Sugar Diet' and 'Dr. Gott's No Flour, No Sugar Cookbook', which are available at most bookstores or online. His website is www.AskDrGottMD.com. Contact him c/o United Media, 200 Madison Avenue, fourth floor, New York, New York 10016.