LONDON, March 6 (Reuters) — Bayern Munich stamped their authority on the UEFA Cup on Thursday, hammering five goals past 10-man Anderlecht in Brussels in their last 16 first leg tie.

Goals from Hamit Altintop and Luca Toni in the first half and Lukas Podolski and substitutes Miroslav Klose and Franck Ribery in the second ensured four-times European champions Bayern a gentle workout in the second leg at home next week.

It was Anderlecht's heaviest European defeat at home and followed a red card for Marcin Wasilewski just before halftime.

In a heavyweight last 16 boasting four other former European champions, PSV Eindhoven won 1-0 at Tottenham Hotspur when Peru striker Jefferson Farfan stole the ball from Gilberto in the 34th minute and fired into the corner.

The result puts coach Juande Ramos's hopes of a UEFA Cup hat-trick in peril. Ramos took Sevilla to the title in 2006 and 2007.

Gavin McCann scored for fellow Premier League side Bolton Wanderers in a 1-1 draw at home to Portugal's Sporting.

McCann hit home a rebound after Matthew Taylor's 25th minute shot was blocked, while Sporting replied in the 69th through Simon Vukcevic to take a valuable away goal back to Lisbon.

The third English side in the competition, Everton, were beaten 2-0 away to Fiorentina.

Keeper Tim Howard made a spectacular double save midway through the second half but could not keep out Zdravko Kuzmanovic who fired home in the 70th minute from 20 metres.

Riccardo Montolivo added the second with a well-struck volley after a fine passing move nine minutes from time.

Two goals from Djibril Cisse, either side of a strike from Senegal forward Mamadou Niang earned former Champions League winners Olympique Marseille a 3-1 home win over Zenit St Petersburg.

Andrei Arshavin got one back for the Russians in the 82nd minute.

The German derby at Bayer Leverkusen ended in a 1-0 win for the home side against former European champions Hamburg SV, Theofanis Gekas's 77th-minute strike proving the difference between the teams.

The fourth German side still in the competition, Werder Bremen, tumbled to a 2-0 defeat at Rangers in Glasgow.

Goals either side of halftime from Daniel Cousin, whose shot goalkeeper Tim Wiese failed to hold, and Steven Davis, who poked home a rebound, gave the Scots a toe-hold in the quarter-finals.

Getafe crossed the border into Portugal and returned with a two away goals from a 2-1 victory at Jose Camacho's Benfica, twice European Cup winners in the early 1960s.

The home side played all but 10 minutes of the game with 10 men after forward Oscar Cardozo was sent off for a foul on Belenguer.

Midfielder Ruben de la Red took advantage in the 25th minute and Pablo Hernandez made it 2-0 in the 67th before substitute Mantorras got one back for the Portuguese.