Premier League clubs reach their final match before the international break and Fantasy managers should look to Newcastle United players such as goalkeeper Nick Pope and forward Alexander Isak as the Magpies play six of the bottom nine teams in their next seven games.

Saturday

Brentford v Bournemouth (11am)

Brentford were narrowly beaten at Fulham on Monday to fall into the bottom half of the table. Aaron Hickey, Josh Dasilva, Gustavo Nunes and Igor Thiago are out to various injuries this week, while Rico Henry and Kristoffer Ajer are doubtful

Bournemouth stunned Manchester City to climb within three points of the top four last week. Kepa Arrizabalaga, Alex Scott and Luis Sinisterra are injured and Dango Ouattara is doubtful with a muscle injury.

Prediction: 2-1

Crystal Palace v Fulham (11am)

Crystal Palace followed up their first win of the campaign with a comeback draw at Wolves. Will Hughes is suspended this week after picking up five yellow cards. Chadi Riad, Eberechi Eze, Jefferson Lerma, Matheus Franca and Adam Wharton are injured, with Chris Richards and Joel Ward doubtful.

Fulham forward Harry Wilson scored two goals in stoppage time to clinch victory over Brentford. Sasa Lukic is out with a shoulder injury, the only player unavailable this week for the Cottagers.

Prediction: 1-1

West Ham United v Everton (11am)

It has been widely reported that Julen Lopetegui could be sacked if West Ham lose this game after they were humiliated 3-0 by Nottingham Forest last week. Mohamed Kudus and Edson Alvarez are suspended, while Nicklas Fullkrug remains out with an Achilles injury.

Everton have conceded only three goals in their last five games. James Garner, Tim Iroegbunam, Armando Broja and Youssef Chermiti are injured this match, while Abdoulaye Doucoure is doubtful.

Prediction: 0-2

Wolverhampton Wanderers v Southampton (11am)

Wolves remain winless after squandering a second-half lead to draw at Crystal Palace. Yerson Mosquera, Boubacar Traore, Enso Gonzalez, Hwang Hee-Chan and Sasa Kalajdzic are out to knee and ankle injuries, while Bastien Meupiyou and Mario Lemina are doubtful.

Southampton claimed their first win of the season at home to Everton last week. Goalkeeper Gavin Bazunu, Will Smallbone and Ross Stewart are out with injuries and Ryan Fraser is doubtful.

Prediction: 2-1

Brighton & Hove Albion v Manchester City (1.30pm)

Brighton were punished for poor first-half finishing in their loss at Liverpool last week. Adam Webster and James Milner are out with hamstring injuries, while Solly March, Yankuba Minteh, Yasin Ayari, Matt O’Riley and Lewis Dunk are doubtful.

Manchester City have lost three games in a row in all competitions for the first time since 2018 and have conceded eight goals in those matches. Ruben Dias, Oscar Bobb and Jack Grealish will miss this match, Rodri is out for the season and John Stones remains doubtful with a foot injury.

Prediction: 3-2

Liverpool v Aston Villa (4pm)

Liverpool have made their best start in club history, winning 14 of their first 16 games and losing just once. Alisson, Diogo Jota, Harvey Elliott and Federico Chiesa are out injured this weekend.

Aston Villa are winless in four games in all competitions, including suffering a heavy defeat at Tottenham last week. Ross Barkley is out with an unknown injury, while Matt Cash and Morgan Rogers are doubtful this match.

Prediction: 2-1

Sunday

Manchester United v Leicester City (10am)

Manchester United have gone unbeaten in three games under interim coach Ruud van Nistelrooy, for whom this is his last game. Luke Shaw remains out with a calf injury, while Harry Maguire, Tyrell Malacia, Leny Yoro, Antony, Kobbie Mainoo, Mason Mount and Christian Eriksen are doubtful.

Leicester hit double digits in points with their draw at Ipswich last time. Jakub Stolarczyk is out with an ankle injury, while Hamza Choudhury and Patson Daka are doubtful.

Prediction: 2-0

Nottingham Forest v Newcastle United (10am)

Nottingham Forest have marked three straight victories to jump to their highest-ever league position after ten games. Danilo (ankle) and Ibrahim Sangare (hamstring) are out this week.

Newcastle striker Alexander Isak scored his third goal in three matches against Arsenal in victory last Saturday. Sven Botman, Jamaal Lascelles, Kieran Trippier and Callum Wilson are out, while Matt Targett and Jacob Murphy are doubtful.

Prediction: 1-2

Tottenham Hotspur v Ipswich Town (10am)

Tottenham demolished Aston Villa last week and travelled to Turkish giants Galatasaray on Thursday. Micky van de Ven and Wilson Odobert will miss this match with hamstring injuries, while Cristian Romero, Djed Spence and Richarlison are doubtful to various injuries.

Ipswich are one of just two winless teams (Leicester) left in the top flight, and they have dropped 12 points from winning positions, the second most in the league. Kalvin Phillips is suspended for three games after being sent off against Leicester last time, while Isaiah Greaves, Axel Tuanzebe, Jack Taylor and Chiedozie Ogbene are out with injuries.

Prediction: 3-1

Chelsea v Arsenal (12.30pm)

Chelsea were held to a draw at Manchester United but still have the third-best scoring record in the league. Omari Kellyman is out with a hamstring injury this week, while Cole Palmer is doubtful.

Arsenal are winless in four games in all competitions after being shut out at Inter Milan in the Champions League in midweek. Raheem Sterling cannot face his parent club to league loan rules, while Kieran Tierney, Takehiro Tomiyasu and Riccardo Calafiori are out injured. Martin Odegaard is doubtful.

Prediction: 2-2