Southampton were the first team to be relegated after their loss at Tottenham Hotspur last week and the Saints could still become the worst team in Premier League history despite sacking head coach Ivan Juric.

Fantasy managers should make the most of the double gameweek for Newcastle, who host Manchester United and Crystal Palace. Tino Livramento, Jacob Murphy and Alexander Isak are solid selections as the Magpies look to continue their winning form.

Saturday

Manchester City v Crystal Palace (8.30am)

Manchester City drew 0-0 with Manchester United in a dreary game last weekend and have Manuel Akanji, Nathan Ake, John Stones, Rodri and Erling Haaland out injured.

Crystal Palace have dropped just two points in their last five league games but have Marc Guehi and Eddie Nketiah suspended. Chadi Riad and Cheick Doucoure are out injured, while Chris Richards and Maxence Lacroix are doubtful.

Prediction: 2-2

Brighton & Hove Albion v Leicester City (11am)

Brighton lost to in-form Crystal Palace last week. Jan Paul van Hecke is suspended after being sent off in that game, while Jason Steele, Igor Julio, Tariq Lamptey, Joel Veltman, Adam Webster, Ferdi Kadioglu, James Milner and Georginio Rutter are injured.

Leicester will surely be relegated soon after suffering their 22nd defeat of the campaign at home to Newcastle. Facundo Buonanotte cannot face his parent club to league loan rules.

Prediction: 2-0

Nottingham Forest v Everton (11am)

Nottingham Forest lost for just the fourth time in 17 league games at Aston Villa last weekend. Ola Aina will miss this match with a calf injury, while Anthony Elanga, Taiwo Awoniyi and Chris Wood are doubtful.

Everton recorded their fourteenth draw of the season at home to Arsenal last week. Jesper Lindstrom, Orel Mangala and Dominic Calvert-Lewin are out injured, with Vitalii Mykolenko doubtful.

Prediction: 1-1

Southampton v Aston Villa (11am)

Southampton need two points from their final seven games to avoid being labelled the worst team in Premier League history. Flynn Downes remains suspended, while Juan Larios Lopez and Albert Gronbaek are doubtful.

Aston Villa lost to PSG in the Champions League in midweek but have won three consecutive league matches. Leon Bailey and Ross Barkley are doubts this weekend.

Prediction: 0-3

Arsenal v Brentford (1.30pm)

Arsenal will need to come back to earth after their dominant Champions League win over Real Madrid midweek. Gabriel Magalhaes, Takehiro Tomiyasu, Riccardo Calafiori, Gabriel Jesus and Kai Havertz will miss this game.

Brentford have picked up just three wins in eight league matches. Aaron Hickey, Josh Dasilva, Fabio Carvalho, Gustavo Nunes and Igor Thiago are out injured for this trip to a buoyant Emirates.

Prediction: 2-0

Sunday

Chelsea v Ipswich Town (10am)

Chelsea were held to a goalless draw at Brentford last weekend. Mykhailo Mudryk remains suspended after a failed drugs test and Wesley Fofana, Omari Kellyman and Romeo Lavia are out injured. Marc Guiu is doubtful with a hamstring injury.

Ipswich lost at home to Wolves last week to slip 12 points from safety. Wes Burns, Sammie Szmodics and Chiedozie Ogbene are out injured, while Omari Hutchinson is doubtful.

Prediction: 1-1

Liverpool v West Ham United (10am)

Liverpool succumbed to just their second loss of the season at Fulham. Trent Alexander-Arnold and Joe Gomez are out this weekend, while Alisson Becker and Tyler Morton are doubtful.

West Ham drew with Bournemouth last week and striker Niclas Fullkrug returning from injury appears to have added more of a goal threat. Crysencio Summerville and Michail Antonio are out injured for this match.

Prediction: 2-0

Wolverhampton Wanderers v Tottenham Hotspur (10am)

Wolves have all but secured safety after the comeback win at Ipswich last time out. Yerson Mosquera, Enso Gonzalez, Leon Chiwome and Sasa Kalajdzic are out injured.

Mathys Tel scored his first goal for Tottenham in the win over Southampton. Radu Dragusin, Kevin Danso and Dejan Kulusevski are out injured.

Prediction: 2-1

Newcastle United v Manchester United (12.30pm)

Newcastle are on a four-match winning streak, including the Carabao Cup final. Sven Botman, Lewis Hall and Jamaal Lascelles are injured, while Joe Willock and Anthony Gordon are doubtful.

Manchester United stayed strong defensively to take a goalless draw against City on Sunday. Jonny Evans, Lisandro Martinez, Ayden Heaven and Amad Diallo are out injured, while Matthijs de Ligt and Kobbie Mainoo are doubtful

Prediction: 2-2

Monday

Bournemouth v Fulham (4pm)

Bournemouth have won just one of their last six league games after the draw at West Ham last week. Ryan Christie and Enes Unal are out to groin and knee injuries respectively, while Justin Kluivert, Luis Sinisterra and Marcus Tavernier are doubtful.

Fulham have taken four points against the incoming Premier League champions after beating Liverpool at Craven Cottage last weekend. Reiss Nelson is out with a hamstring injury this weekend, while Harry Wilson is doubtful with a foot injury.

Prediction: 1-2

Wednesday, April 16

Newcastle United v Crystal Palace (4pm)

Newcastle have 12 wins to Palace’s six through 27 league meetings, but three of the last five have ended all square.

Prediction: 2-0